Orlistat 96829-58-2 Kaabista Cunnada Kahortagga Cayilka
Lacag bixintaT/T, L/C
Asal ahaan badeecada:Shiinaha
Dekadda Rarida:Beijing/Shanghai/Hangzhou
Awoodda wax-soo-saarka:800kg/bishii
Dalbo (MOQ):25kg
Waqtiga Hogaaminta:3 Maalmo Shaqo
Xaaladda kaydinta:Lagu kaydiyaa qabow, meel qalalan, heerkulka qolka.
Qalabka xirmada:durbaan
Cabbirka xirmada:25kg/durbaan
Macluumaadka badbaadada:Maaha alaab khatar ah
Hordhac
Orlistat waa wax-qabad dheer oo awood leh oo gaar ah oo ilaaliya lipase-ga caloosha.Waa cad ama budo cad oo ku dhow heerkulka qolka, taas oo aan biyo ku milmin, ku milma chloroform, si fududna ugu milmi kara ethanol.Waxa ay hawlgelisaa enzyme-ka iyada oo samaysa xidhidhyo isku xidhan oo leh goobaha serine ee firfircoon ee lipase gastric iyo lipase ganaca ee caloosha iyo xiidmaha yar.
Orlistat waa nooc ka mid ah lipase inhibitor miisaan lumis.Waa dheecaan laga soo saaray lipstatin, kaas oo yarayn kara nuugista dufanka cuntada iyo dhimista miisaanka.Alaabtani waxay leedahay xannibaad xooggan oo xulashada ah ee lipase gastric iyo lipase pancreatic, wax saameyn ah kuma laha enzymes dheefshiidka kale (amylase, trypsin, chymotrypsin) iyo phospholipase, mana saameeyaan nuugista karbohaydraytyada, borotiinnada iyo phospholipids.Waxay joojisaa enzyme-ka inta badan iyada oo loo marayo isku-xirnaanta isku-dhafka ah ee haraaga serine-ka ee goobaha firfircoon ee lipase gastric iyo pancreatic lipase ee mareenka caloosha iyo mindhicirka, waxay joojisaa hydrolysis ee triacylglycerol, waxay yareysaa qaadashada monoglyceride iyo dufanka dufanka leh ee bilaashka ah, sidaas awgeedna waxay xakameysaa miisaanka jirka.Daawada laguma nuugo mareenka caloosha iyo mindhicirka, iyo xannibaadda lipase waa la bedeli karaa.
Alaabtani waxay sidoo kale leedahay shaqada nidaaminta xuubka dhiigga.Waxay hoos u dhigi kartaa triglyceride iyo kolestaroolka lipoprotein cufnaanta hoose ee serum ee bukaanka buuran waxayna kordhisaa saamiga lipoprotein-cufnaanta sare ilaa lipoprotein-cufnaanta hoose.
Marka Orlistat lagu daro cunto kalooriye yar, waxay ku habboon tahay daaweynta muddada-dheer ee dadka cayilan iyo kuwa cayilan, oo ay ku jiraan kuwa soo saaray arrimaha khatarta ah ee buurnaanta.Waxay leedahay shaqada xakamaynta miisaanka muddada dheer sida miisaan dhimista, dayactirka miisaanka iyo ka hortagga soo noqoshada.Kiliinikada waxay si cad u muujineysaa in shaqada xakameynta culeyska ay aad faa'iido u leedahay isticmaalka muddada dheer marka shirkadda la cunayo ama ka dib hal saac oo cunto ah.
Orlistat wuxuu yarayn karaa heerka dhacdooyinka buurnida laxiriira khatarta iyo cudurada kale ee laxiriira buurnaanta, oo ay kujiraan hypercholesterolemia, nooca 2aad ee sonkorowga, dulqaadka gulukooska ee daciifka ah, hyperinsulinemia, hypertension, wuxuuna yareeyaa dufanka ku jira xubnaha.
Tilmaamaha (USP42)
| Shayga | Tilmaamid |
| Aqoonsiga | HPLC, IR |
| Wareegga indhaha ee gaarka ah | -48.0°~-51.0° |
| Biyaha ku jira | ≤0.2% |
| Walxaha laxidhiidha I | Isku dhafka Orlistat A ≤0.2% |
| Walxaha laxidhiidha II | Isku dhafka Orlistat B ≤0.05% |
| Walxaha laxidhiidha III
| Formylleucine ≤0.2% |
| Isku dhafka Orlistat C ≤0.05% | |
| Orlistat epimer giraanta furan ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Nijaasnimo shakhsi ah oo aan la aqoonsan ≤0.1% | |
| Waxyaabaha la xidhiidha IV | Isku dhafka Orlistat D ≤0.2% |
| Orlistat giraanta furan amide ≤0.1% | |
| Walxaha la xidhiidha V | Isku dhafka Orlistat E ≤0.2% |
| Wadarta wasakhda (I ilaa V) | ≤1.0% |
| Haraaga dareerayaasha | Methanol ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Hadhaaga dabka | ≤0.1% |
| Biraha culus sida Pb | ≤20pm |
| Qiimaynta HPLC | 98.0% ~ 101.5% (ku salaysan anhydrous, dareere-free) |
