Tacrolimus monohydrate 109581-93-3 Antibiyootiko
Lacag bixintaT/T, L/C
Asal ahaan badeecada:Shiinaha
Dekadda Rarida:Beijing/Shanghai/Hangzhou
Awoodda wax-soo-saarka:1kg/bishii
Dalbo (MOQ):1g
Waqtiga Hogaaminta:3 Maalmo Shaqo
Xaaladda kaydinta:Lagu kaydiyaa qabow, meel qalalan, heerkulka qolka.
Qalabka xirmada:dhalo, dhalada
Cabbirka xirmada:1g/fijaal, 5/fijaale, 10g/dhalo, 50g/dhalo, 500g/dhalo
Macluumaadka badbaadada:UN 2811 6.1/PG 3
Hordhac
Tacrolimus, waa daawada difaaca jirka.Ka dib wareejinta xubnaha allogeneic, khatarta diidmada xubnaha waa dhexdhexaad.Si loo yareeyo khatarta diidmada xubnaha, tacrolimus ayaa la bixiyaa.Daawada waxa kale oo loo iibin karaa dawo la mariyo oo lagu daweeyo cudurrada T-cell-dhexdhexaadinta ah sida cambaarta iyo psoriasis.Waxa loo isticmaali karaa in lagu daweeyo isha qalalan ee bisadaha iyo eeyaha.
Tacrolimus waxay joojisaa calcineurin, taas oo ku lug leh soo saarista interleukin-2, molecule kor u qaada horumarinta iyo fidinta unugyada T, taas oo qayb ka ah jawaabta jidhka ee la bartay (ama la qabsiga).
Tilmaamaha (USP43)
| Shayga | Tilmaamid |
| Muuqashada | Caddaan ama ku dhawaad cad budo crystalline |
| Aqoonsiga | IR, HPLC |
| Solubility | Aad ugu milmay methanol, si xor ah ugu milmay N,N dimethylformamide iyo alkohol, ficil ahaan ku milmay biyaha. |
| Hadhaaga dabka | ≤0.10 % |
| wasakhda dabiiciga ah (habraaca-2) | Ascomycin 19-epimer ≤0.10% |
| Ascomycin ≤0.50 % | |
| Desmethyl tacrolimus ≤0.10% | |
| Tacrolimus 8-epimer ≤0.15% | |
| Tacrolimus 8-propyl analoog ≤0.15 % | |
| wasakh aan la aqoon -I ≤0.10 % | |
| wasakh aan la aqoon -II ≤0.10 % | |
| wasakh aan la aqoon -III ≤0.10 % | |
| Wadarta wasakhda ≤1.00 % | |
| Wareegga indhaha (sida ku saleysan) (10mg/ml ee N, Ndimethylformamide) | -110.0° ~ -115.0° |
| Waxyaabaha biyaha ka kooban (waxaa qoray KF) | ≤4.0% |
| Walxaha haraaga ah (waxaa qoray GC) | Acetone ≤1000ppm (guriga gudihiisa) |
| Di-isopropyl ether ≤100ppm (guriga gudihiisa) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Tijaabada microbial (guriga dhexdiisa) | Wadarta tirada microbial aerobic ≤100cfu/gm |
| Wadarta tirada khamiirka iyo caaryada ≤10cfu/gm | |
| Noolaha la cayimay (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) waa inay maqan yihiin | |
| Qiimaynta (by HPLC) (oo ku salaysan dareeraha iyo dareeraha bilaashka ah) | 98% ~ 102% |
