Alaabta

Glutathione waxay ku dhici kartaa hoos u dhac (GSH), oxidized (GSSG), ama foomamka disulfide ee isku dhafan waxayna meel walba ku yaalaan habab badan oo bayooloji ah oo u adeegaya sida thiol-disulfide redox-ka weyn ee unugyada.Glutathione, Oxidized (GSSG) waa nooca oksaydhka ee glutathione ee dabiiciga ah oo aad muhiim u ah (GSH).In vivo GSSG waxaa dib loogu soo celinayaa GSH iyada oo loo sii marayo NADPH-ku-tiirsanaanta enzyme glutathione reductase.Saamiga GSH iyo GSSG waxaa inta badan loo isticmaalaa in lagu qiyaaso heerka cadaadiska oksaydhiyaha ee unugyada, iyada oo uruurinta sare ee GSSG ay tusinayso walbahaarka oksaydhismka oo dheeraad ah, sidaas darteed beeing bioindicator muhiim ah ee caafimaadka gacanta.GSSG waxay u shaqeysaa sidii aqbale haydarojiin go'aaminta enzymatic ee NADP+ iyo NADPH waxayna noqon kartaa deeq bixiye u dhow S-glutathionylation beddelka tarjumaada kadib.GSSG, oo ay weheliso glutathione iyo S-nitrosoglutathione (GSNO), ayaa la ogaaday inay ku xidhan yihiin goobta aqoonsiga glutamate ee NMDA iyo AMPA reseptors (iyada oo loo sii marayo γ-glutamyl unugyadooda), waxayna noqon karaan neuromodulators endogenous.GSSG waxa loo isticmaali karaa substrate si enzymatically lagu qiimeeyo glutathione reductase.