Amphotericin B 1397-89-3 Antibiyootiko
Lacag bixintaT/T, L/C
Asal ahaan badeecada:Shiinaha
Dekadda Rarida:Beijing/Shanghai/Hangzhou
Awoodda wax-soo-saarka:100kg/bishii
Dalbo (MOQ):25kg
Waqtiga Hogaaminta:3 Maalmo Shaqo
Xaaladda kaydinta:bac baraf ah oo loogu talagalay gaadiidka.Ku kaydi at 2-8 ℃ muddo dheer.
Qalabka xirmada:durbaan
Cabbirka xirmada:25kg/durbaan
Macluumaadka badbaadada:Maaha alaab khatar ah
Hordhac
Amphotericin B, waxaa loogu yeeri karaa sida Fungizone ama Ambisome, kaas oo ah antibiyootig antifungal polyene ah oo ka go'an dhexdhexaad dhaqameedka Streptomycesnodosus.Waxay u kala go'day laba qaybood oo leh A iyo B, laakiin qayb ayaa ku yar shaqada antifungal ee aan la isticmaalin, markaa dadku waxay isticmaalaan qaybta B oo kaliya oo loo yaqaan 'Amphotericin B'.
Waa daawo fangas-ka-hortagga ah oo loo isticmaalo infekshannada fangas-ka halista ah iyo leishmaniasis.Waxay leedahay laba isticmaal oo kala duwan oo afka iyo duritaanka ah.
Amphotericin B waa doorashada koowaad ee caabuqa fangas qoto dheer sababtoo ah spectrum antifungal ballaaran.Waxay xakameysaa shaqada fangas sida cryptococcus, coccidium, candida albicans iyo blastomycetes, iwm
Tilmaamaha caafimaad ee ugu waaweyn sida: 1. Daaweynta fangas sida cryptococcosis, blastomycosis North America, candidiasis la faafiyay, coccidiosis iyo histoplasmosis.2. Daawaynta mucormycosis oo ay sababto qaar ka mid ah fungals sida Rhizopus, colporium, endomycetes iyo caaryada saxarada raha.3. Daawaynta sporotrichosis ee uu keeno sporotrichosis schenckii.4. Daawaynta aspergillosis ee uu keeno Aspergillus fumigatus.5. Diyaargarowga jirka ayaa ku habboon mycosis midab leh.Waxay sidoo kale ku habboon tahay caabuqa fangas maqaarka ka dib gubashada, mareenka neef-mareenka Candida iyo Aspergillus ama caabuqa cryptococcus, iyo sidoo kale shaqada fungal fungal boogaha.
Waxyeellooyinka caadiga ah waxaa ka mid ah falcelinta qandho, qarqaryo, iyo madax-xanuun isla markiiba ka dib daawada, iyo sidoo kale dhibaatooyinka kelyaha.Calaamadaha xasaasiyadda oo ay ku jiraan anaphylaxis ayaa dhici karta.Dhibaatooyinka kale ee halista ah waxaa ka mid ah potassium dhiigga oo hooseeya iyo bararka wadnaha.Waxay u muuqataa mid ilaa xad ammaan ah uurka.Waxaa jira qaab-dhismeedka dufanka leh oo leh khatar hoose oo waxyeellooyin ah.Waxay ku jirtaa fasalka polyene ee daawooyinka waxayna ka shaqeysaa qayb ahaan iyadoo faragalinaysa xuubka unugyada fungus.Waa in si taxadar leh loo isticmaalo marka ay xaaladuhu dhacaan, isticmaalka badbaadada waa inuu raacaa talada shaqaalaha caafimaadka.
Gaaritaanka Darajada Afka (Heerka Guriga)
| Shayga | Tilmaamid |
| Muuqashada | Jaalle ilaa liimi-jaale budo ah, aan ur lahayn ama ku dhawaad ur lahayn. |
| Aqoonsiga | IR, HPLC |
| pH | 4.0-6.0 |
| Khasaare xagga qalajinta | ≤5.0% |
| Sulfated Ash | ≤3.0% |
| Walxaha laxidhiidha | ≤0.5% |
| 303nm | wasakh A (Amphotericin A) ≤5.0% Nijaasnimo shakhsi ah oo aan la garanayn ≤1.0% |
| 383nm | wasakhda B (Amphotericin X1) ≤4.0% Nijaasnimo shakhsi ah oo aan la garanayn ≤2.0% |
| Wadarta wasakhda | ≤15.0% |
| Haraaga dareerayaasha | Methanol ≤0.3% Acetone ≤0.5% |
| Qiimayn | ≥850 amphotericin B unug/mg ee walaxda la qalajiyey. |
Gaaritaanka Darajada Afka (Heerka Guriga)
| Shayga | Tilmaamid |
| Muuqashada | Jaalle ilaa liimi ah oo aan budo lahayn. |
| Aqoonsiga | IR, HPLC |
| Hadhaaga dabka | ≤0.5% |
| Walxaha la xidhiidha |
|
| 303nm | Amphotericin A ≤2.0% |
| Nijaasnimo shakhsi ah oo aan la garanayn ≤1.0% | |
| 383 nm | Amphotericin X1 ≤4.0% |
| Nijaasnimo shakhsi ah oo aan la garanayn ≤2.0% | |
| Wadarta wasakhda | ≤15.0% |
| Haraaga dareerayaasha | Acetone ≤0.5% |
| Methanol ≤0.3% | |
| Xadka Microbiological | Tirada microbial Aerobic ≤1000cfu/g |
| Caaryada & khamiirka ≤100cfu/g | |
| Escherichia coli Maqnaanshaha 1g | |
| Bakteeriyada endotoxins | <1.0EU/mg |
| Qiimayn | ≥850 amphotericin B halbeeg/mg, oo lagu xisaabiyey sal engegan |
